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  1. The antihypertensive effect persists for 24 hours after dosing, but there is a decrease from peak effect at lower doses (40 mg) presumably reflecting loss of tretinoin cream inhibition of tretinoin cream angiotensin. Prednisone 20 mg is prescribed for treatment of varied indications like asthma, rheumatic disorders, copd, adrenocortical insufficiency, cancer related hypercalcema, thyroiditis, ulcerative colitis, severe tuberculosis, nephritic syndrome and many serious conditions.