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Patients Figure kamagra best price 1 https://carlyabbott.com/cheap-kamagra-pills-uk/. Figure 1 kamagra best price. Enrollment and Randomization. Of the 1114 patients who were assessed for eligibility, 1062 underwent kamagra best price randomization.

541 were assigned to the remdesivir group and 521 to the placebo group (intention-to-treat population) (Figure 1). 159 (15.0%) were categorized as having mild-to-moderate disease, and 903 (85.0%) were in the kamagra best price severe disease stratum. Of those assigned to receive remdesivir, 531 patients (98.2%) received the treatment as assigned. Fifty-two patients had remdesivir treatment discontinued before day 10 because of an adverse kamagra best price event or a serious adverse event other than death and 10 withdrew consent.

Of those assigned to receive placebo, 517 patients (99.2%) received placebo as assigned. Seventy patients discontinued placebo before day 10 because of an adverse event or a serious adverse event other than kamagra best price death and 14 withdrew consent. A total of 517 patients in the remdesivir group and 508 in the placebo group completed the trial through day 29, recovered, or died. Fourteen patients who kamagra best price received remdesivir and 9 who received placebo terminated their participation in the trial before day 29.

A total of 54 of the patients who were in the mild-to-moderate stratum at randomization were subsequently determined to meet the criteria for severe disease, resulting in 105 patients in the mild-to-moderate disease stratum and 957 in the severe stratum. The as-treated population included 1048 patients who received the assigned treatment (532 in the remdesivir group, including one patient who had kamagra best price been randomly assigned to placebo and received remdesivir, and 516 in the placebo group). Table 1. Table 1 kamagra best price.

Demographic and Clinical Characteristics of the Patients at Baseline. The mean kamagra best price age of the patients was 58.9 years, and 64.4% were male (Table 1). On the basis of the evolving epidemiology of erectile dysfunction treatment during the trial, 79.8% of patients were enrolled at sites in North America, 15.3% in Europe, and 4.9% in Asia (Table S1 in the Supplementary Appendix). Overall, 53.3% of the patients were White, 21.3% kamagra best price were Black, 12.7% were Asian, and 12.7% were designated as other or not reported.

250 (23.5%) were Hispanic or Latino kamagra best price. Most patients had either one (25.9%) or two or more (54.5%) of the prespecified coexisting conditions at enrollment, most commonly hypertension (50.2%), obesity (44.8%), and type 2 diabetes mellitus (30.3%). The median number of days kamagra best price between symptom onset and randomization was 9 (interquartile range, 6 to 12) (Table S2). A total of 957 patients (90.1%) had severe disease at enrollment.

285 patients (26.8%) met category 7 criteria on the ordinal kamagra best price scale, 193 (18.2%) category 6, 435 (41.0%) category 5, and 138 (13.0%) category 4. Eleven patients (1.0%) had missing ordinal scale data at enrollment. All these patients discontinued the study before kamagra best price treatment. During the study, 373 patients (35.6% of the 1048 patients in the as-treated population) received hydroxychloroquine and 241 (23.0%) received a glucocorticoid (Table S3).

Primary Outcome Figure 2 kamagra best price. Figure 2. Kaplan–Meier Estimates of kamagra best price Cumulative Recoveries. Cumulative recovery estimates are shown in the overall population (Panel A), in patients with a baseline score of 4 on the ordinal scale (not receiving oxygen.

Panel B), in those with a baseline score of 5 (receiving kamagra best price oxygen. Panel C), in those with a baseline score of 6 (receiving high-flow oxygen or noninvasive mechanical ventilation. Panel D), and in those with a kamagra best price baseline score of 7 (receiving mechanical ventilation or extracorporeal membrane oxygenation [ECMO]. Panel E).Table 2.

Table 2 kamagra best price. Outcomes Overall and According to Score on the Ordinal Scale kamagra best price in the Intention-to-Treat Population. Figure 3. Figure 3 kamagra best price.

Time to Recovery According to Subgroup. The widths of kamagra best price the confidence intervals have not been adjusted for multiplicity and therefore cannot be used to infer treatment effects. Race and ethnic group were reported by the patients.Patients in the remdesivir group had a shorter time to recovery than patients in the placebo group (median, 10 days, as compared with 15 days. Rate ratio kamagra best price for recovery, 1.29.

95% confidence interval [CI], 1.12 to 1.49. P<0.001) (Figure 2 kamagra best price and Table 2). In the severe disease stratum (957 patients) the median time to recovery was 11 days, as compared with 18 days (rate ratio for recovery, 1.31. 95% CI, 1.12 kamagra best price to 1.52) (Table S4).

The rate ratio for recovery was largest among patients with a baseline ordinal score of 5 (rate ratio for recovery, 1.45. 95% CI, kamagra best price 1.18 to 1.79). Among patients with a baseline score of 4 and those with a baseline score of 6, the rate ratio estimates for recovery were 1.29 (95% CI, 0.91 to 1.83) and 1.09 (95% CI, 0.76 to 1.57), respectively. For those receiving mechanical ventilation or ECMO at enrollment (baseline ordinal score of 7), kamagra best price the rate ratio for recovery was 0.98 (95% CI, 0.70 to 1.36).

Information on interactions of treatment with baseline ordinal score as a continuous variable is provided in Table S11. An analysis adjusting for baseline ordinal score as a covariate was conducted to evaluate the overall effect (of the percentage of patients in each ordinal score category at baseline) on the kamagra best price primary outcome. This adjusted analysis produced a similar treatment-effect estimate (rate ratio for recovery, 1.26. 95% CI, 1.09 to kamagra best price 1.46).

Patients who underwent randomization during the first 10 days after the onset of symptoms had a rate ratio for recovery of 1.37 (95% CI, 1.14 to 1.64), whereas patients who underwent randomization more than 10 days after the onset of symptoms had a rate kamagra best price ratio for recovery of 1.20 (95% CI, 0.94 to 1.52) (Figure 3). The benefit of remdesivir was larger when given earlier in the illness, though the benefit persisted in most analyses of duration of symptoms (Table S6). Sensitivity analyses in which data were censored kamagra best price at earliest reported use of glucocorticoids or hydroxychloroquine still showed efficacy of remdesivir (9.0 days to recovery with remdesivir vs. 14.0 days to recovery with placebo.

Rate ratio, kamagra best price 1.28. 95% CI, 1.09 to 1.50, and 10.0 vs. 16.0 days kamagra best price to recovery. Rate ratio, 1.32.

95% CI, 1.11 kamagra best price to 1.58, respectively) (Table S8). Key Secondary Outcome The odds of improvement in the ordinal scale score were higher in the remdesivir group, as determined by a proportional odds model at the day 15 visit, than in the placebo group (odds ratio for improvement, 1.5. 95% CI, 1.2 to 1.9, kamagra best price adjusted for disease severity) (Table 2 and Fig. S7).

Mortality Kaplan–Meier estimates kamagra best price of mortality by day 15 were 6.7% in the remdesivir group and 11.9% in the placebo group (hazard ratio, 0.55. 95% CI, 0.36 to 0.83). The estimates by day 29 were 11.4% and 15.2% in two kamagra best price groups, respectively (hazard ratio, 0.73. 95% CI, 0.52 to 1.03).

The between-group differences in mortality kamagra best price varied considerably according to baseline severity (Table 2), with the largest difference seen among patients with a baseline ordinal score of 5 (hazard ratio, 0.30. 95% CI, 0.14 to 0.64). Information on interactions of treatment with baseline kamagra best price ordinal score with respect to mortality is provided in Table S11. Additional Secondary Outcomes Table 3.

Table 3 kamagra best price. Additional Secondary kamagra best price Outcomes. Patients in the remdesivir group had a shorter time to improvement of one or of two categories on the ordinal scale from baseline than patients in the placebo group (one-category improvement. Median, 7 kamagra best price vs.

9 days. Rate ratio for recovery, 1.23 kamagra best price. 95% CI, 1.08 to 1.41. Two-category improvement kamagra best price.

Median, 11 vs. 14 days kamagra best price. Rate ratio, 1.29. 95% CI, 1.12 to 1.48) kamagra best price (Table 3).

Patients in the remdesivir group had a shorter time to discharge or to a National Early Warning Score of 2 or lower than those in the placebo group (median, 8 days vs. 12 days kamagra best price. Hazard ratio, 1.27. 95% CI, kamagra best price 1.10 to 1.46).

The initial length of hospital stay was shorter in the remdesivir group than in the placebo group (median, 12 days vs. 17 days) kamagra best price. 5% of patients in the remdesivir group were readmitted to the hospital, as compared with 3% in the placebo group. Among the 913 patients receiving oxygen at enrollment, those in the remdesivir group continued to receive oxygen for fewer days than patients in the placebo group (median, kamagra best price 13 days vs.

21 days), kamagra best price and the incidence of new oxygen use among patients who were not receiving oxygen at enrollment was lower in the remdesivir group than in the placebo group (incidence, 36% [95% CI, 26 to 47] vs. 44% [95% CI, 33 to 57]). For the 193 patients receiving noninvasive ventilation or high-flow oxygen at enrollment, the median duration of use of kamagra best price these interventions was 6 days in both the remdesivir and placebo groups. Among the 573 patients who were not receiving noninvasive ventilation, high-flow oxygen, invasive ventilation, or ECMO at baseline, the incidence of new noninvasive ventilation or high-flow oxygen use was lower in the remdesivir group than in the placebo group (17% [95% CI, 13 to 22] vs.

24% [95% kamagra best price CI, 19 to 30]). Among the 285 patients who were receiving mechanical ventilation or ECMO at enrollment, patients in the remdesivir group received these interventions for fewer subsequent days than those in the placebo group (median, 17 days vs. 20 days), and the incidence of new mechanical ventilation kamagra best price or ECMO use among the 766 patients who were not receiving these interventions at enrollment was lower in the remdesivir group than in the placebo group (13% [95% CI, 10 to 17] vs. 23% [95% CI, 19 to 27]) (Table 3).

Safety Outcomes In the as-treated population, serious adverse events occurred in 131 of 532 patients (24.6%) in the remdesivir group and in 163 of 516 patients (31.6%) in the placebo group (Table kamagra best price S17). There were 47 serious respiratory failure adverse events in the remdesivir group (8.8% of patients), including acute respiratory failure and the need for endotracheal intubation, and 80 in the placebo group (15.5% of patients) (Table S19). No deaths were considered by kamagra best price the investigators to be related to treatment assignment. Grade 3 or 4 adverse events occurred on or before day 29 in 273 patients (51.3%) in the remdesivir group and in 295 (57.2%) in the placebo group (Table S18).

41 events were judged by kamagra best price the investigators to be related to remdesivir and 47 events to placebo (Table S17). The most common nonserious adverse events occurring in at least 5% of all patients included decreased glomerular filtration rate, decreased hemoglobin level, decreased lymphocyte count, respiratory failure, anemia, pyrexia, hyperglycemia, increased blood creatinine level, and increased blood glucose level (Table S20). The incidence of these adverse events was kamagra best price generally similar in the remdesivir and placebo groups. Crossover After the data and safety monitoring board recommended that the preliminary primary analysis report be provided to the sponsor, data on a total of 51 patients (4.8% of the total study enrollment) — 16 (3.0%) in the remdesivir group and 35 (6.7%) in the placebo group — were unblinded.

26 (74.3%) of those kamagra best price in the placebo group whose data were unblinded were given remdesivir. Sensitivity analyses evaluating the unblinding (patients whose treatment assignments were unblinded had their data censored at the time of unblinding) and crossover (patients in the placebo group treated with remdesivir had their data censored at the initiation of remdesivir treatment) produced results similar to those of the primary analysis (Table S9)..

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I believe the federal government, the CDC, believe they gave comprar kamagra the best guidance they could,” he added. €œI believe the Department of Health gave their best guidance and made the best decisions based on the guidance they had … but that doesn’t mean people didn’t die and people won’t die today or tomorrow.” Click here to sign up for Daily Voice's free daily emails and news alerts..

The United States Department of Justice will determine whether or not to investigate the alleged underreporting of erectile dysfunction treatment deaths in New York kamagra best price nursing homes.White House press secretary Jen Psaki said on Friday, Jan. 29 that it will be up to the Department of Justice to investigate following a report from New York Attorney General Letitia James, which found that the state may have underreported nursing home deaths by upwards of 50 percent.“I’ve kamagra best price seen those reports,” Psaki said during a press briefing on Friday. €œI would say any investigation, I would point to the Department of Justice.“Any investigation would be led by the Department of Justice,” she added when pressed. €œWe’re in a new age where they’re independent and they will determine what path they take moving forward.”Following James’ report, New York Health Commissioner Howard Zucker said the kamagra best price state has recorded 5,957 deaths in long-term care facilities plus another 3,829 in hospitals for a total of 9,786. The previous kamagra best price total shared by the state was just over 8,700.During a erectile dysfunction treatment briefing on Friday, Jan.

29, New York Gov. Andrew Cuomo said solemnly that “everyone did the best they could” when asked about the state’s response to nursing homes during the erectile dysfunction treatment crisis.“The state Department of Health kamagra best price followed the federal guidance, so if you think there was a mistake, then go talk to the federal government. It’s not kamagra best price about point fingers or blame … this all became political football,” he said. €œWhether a person died in a nursing home, or a person died in a hospital, it’s still … people died.”Cuomo noted that New York State still has a lower mortality rate in nursing homes than many other states, even after the numbers were recalculated following the new reports.“I believe everyone did the best they could. I believe the federal kamagra best price government, the CDC, believe they gave the best guidance they could,” he added.

€œI believe the Department of Health gave their best guidance and made the best decisions based on the guidance they had … but that doesn’t mean people didn’t die and people won’t die today or tomorrow.” Click here to sign up for Daily Voice's free daily emails and news alerts..

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REDWOOD CITY, kamagra online paypal Calif.--(BUSINESS WIRE)--Oct look at more info. 16, 2020-- Guardant Health, Inc. (Nasdaq. GH) today announced it will report financial results for the third quarter 2020 after market close on Thursday, November 5, 2020.

Company management will be webcasting a corresponding conference call beginning at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time. Live audio of the webcast will be available on the “Investors” section of the company website at.

Www.guardanthealth.com. The webcast will be archived and available for replay after the event. About Guardant Health Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum.

Guardant Health has launched liquid biopsy-based Guardant360®, Guardant360 CDx, and GuardantOMNI® tests for advanced stage cancer patients. These tests fuel development of its LUNAR program, which aims to address the needs of early stage cancer patients with neoadjuvant and adjuvant treatment selection, cancer survivors with surveillance, asymptomatic individuals eligible for cancer screening and individuals at a higher risk for developing cancer with early detection. View source version on businesswire.com. Https://www.businesswire.com/news/home/20201016005576/en/ Investor Contact.

Carrie Mendivilinvestors@guardanthealth.com Media Contact. Anna Czenepress@guardanthealth.com Courtney Carrollcourtney.carroll@uncappedcommunications.com Source. Guardant Health, Inc.REDWOOD CITY, Calif.--(BUSINESS WIRE)--Oct. 15, 2020-- Guardant Health, Inc.

(Nasdaq why not try here. GH) (“Guardant Health”), a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics, announced today the closings of an underwritten public offering of 7,700,000 shares of its common stock, which includes full exercise of the underwriter’s option to purchase 700,000 shares, at a public offering price of $102.00 per share, before deducting underwriting discounts and commissions, all of which were sold by SoftBank Investment Advisers. The initial closing of 7,000,000 shares occurred on October 9, 2020, and the closing of the underwriter’s option to purchase additional shares occurred today. Guardant Health did not sell any of its shares in the offering and did not receive any of the proceeds from the sale of shares in the offering by SoftBank Investment Advisers.

J.P. Morgan Securities LLC acted as sole book-running manager of the offering. The public offering was made pursuant to an automatic shelf registration statement on Form S-3 that was filed by Guardant Health with the U.S. Securities and Exchange Commission (the “SEC”) and automatically became effective upon filing.

A final prospectus supplement and accompanying prospectus relating to and describing the terms of the offering have been filed with the SEC and are available on the SEC’s website at www.sec.gov. Copies of the final prospectus supplement and accompanying prospectus may be obtained by contacting. J.P. Morgan Securities LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or by telephone at (866) 803-9204, or by email at prospectus-eq_fi@jpmchase.com.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction. Source. Guardant Health, Inc. View source version on businesswire.com.

Https://www.businesswire.com/news/home/20201015005933/en/ Investors. Carrie Mendivilinvestors@guardanthealth.com Media. Anna Czenepress@guardanthealth.comSource. Guardant Health, Inc..

REDWOOD CITY, Calif.--(BUSINESS kamagra best price WIRE)--Oct. 16, 2020-- Guardant Health, Inc. (Nasdaq. GH) today announced it will report financial results for the third quarter 2020 after market close on Thursday, November 5, 2020. Company management will be webcasting a corresponding conference call beginning at 1:30 p.m.

Pacific Time / 4:30 p.m. Eastern Time. Live audio of the webcast will be available on the “Investors” section of the company website at. Www.guardanthealth.com. The webcast will be archived and available for replay after the event.

About Guardant Health Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has launched liquid biopsy-based Guardant360®, Guardant360 CDx, and GuardantOMNI® tests for advanced stage cancer patients. These tests fuel development of its LUNAR program, which aims to address the needs of early stage cancer patients with neoadjuvant and adjuvant treatment selection, cancer survivors with surveillance, asymptomatic individuals eligible for cancer screening and individuals at a higher risk for developing cancer with early detection. View source version on businesswire.com.

Https://www.businesswire.com/news/home/20201016005576/en/ Investor Contact. Carrie Mendivilinvestors@guardanthealth.com Media Contact. Anna Czenepress@guardanthealth.com Courtney Carrollcourtney.carroll@uncappedcommunications.com Source. Guardant Health, Inc.REDWOOD CITY, Calif.--(BUSINESS WIRE)--Oct. 15, 2020-- Guardant Health, Inc.

(Nasdaq. GH) (“Guardant Health”), a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics, announced today the closings of an underwritten public offering of 7,700,000 shares of its common stock, which includes full exercise of the underwriter’s option to purchase 700,000 shares, at a public offering price of $102.00 per share, before deducting underwriting discounts and commissions, all of which were sold by SoftBank Investment Advisers. The initial closing of 7,000,000 shares occurred on October 9, 2020, and the closing of the underwriter’s option to purchase additional shares occurred today. Guardant Health did not sell any of its shares in the offering and did not receive any of the proceeds from the sale of shares in the offering by SoftBank Investment Advisers. J.P.

Morgan Securities LLC acted as sole book-running manager of the offering. The public offering was made pursuant to an automatic shelf registration statement on Form S-3 that was filed by Guardant Health with the U.S. Securities and Exchange Commission (the “SEC”) and automatically became effective upon filing. A final prospectus supplement and accompanying prospectus relating to and describing the terms of the offering have been filed with the SEC and are available on the SEC’s website at www.sec.gov. Copies of the final prospectus supplement and accompanying prospectus may be obtained by contacting.

J.P. Morgan Securities LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or by telephone at (866) 803-9204, or by email at prospectus-eq_fi@jpmchase.com. This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction. Source. Guardant Health, Inc.

View source version on businesswire.com. Https://www.businesswire.com/news/home/20201015005933/en/ Investors. Carrie Mendivilinvestors@guardanthealth.com Media. Anna Czenepress@guardanthealth.comSource. Guardant Health, Inc..

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It also requires states to recruit a diverse group of foster and kamagra online canadian pharmacy adoptive parents to reflect the racial and ethnic makeup of children in out-of-home care. Since MEPA, adoptions have increased by 22 percent from 2005–2007 to 2017–2019. The proportion of transracial adoptions—those in which children are not of the same race as either adoptive parent—also increased, from 21 percent to 28 percent of all adoptions. Despite this progress, hundreds of thousands of children—more than 50 percent kamagra online canadian pharmacy are children of color—currently remain in foster care as they await permanent home placements. In June, the Trump administration issued an executive order that addressed the need to find permanent homes for all children waiting to be adopted.

In support, Mathematica partnered with the Assistant Secretary for Planning and Evaluation (ASPE) to explore trends in adoption and attitudes about MEPA. Our research kamagra online canadian pharmacy uncovered essential data about adoptions in the United States, including. Adoptions of Black children in 2017–2019 were 22 percent lower than in 2005–2007, whereas adoptions of White and Hispanic children increased by 41 percent and 36 percent, respectively, in the same time period. The decline in adoptions of Black children was largely due to a declining number of Black children in foster care over the time period (43 percent less). A child’s race is associated with the time spent in foster care before adoption.

Black children adopted between 2017 and 2019 spent the longest time in foster care before adoption—an average of 33 months—compared to 27 months for White children and 28 months for Hispanic children.Raising awareness of these trends in adoption may help federal and state policymakers focus resources, technical support, and outreach kamagra online canadian pharmacy strategies to states that need to improve their recruitment and retention of a diverse pool of adoptive and foster parents. To learn more about this work, Mathematica and ASPE released several new research products. (1) a detailed summary of the MEPA study. (2) a graphical fact sheet on trends in adoption kamagra online canadian pharmacy and transracial adoption. (3) an analysis of racial disproportionality in adoptive placements.

(4) a report examining the attitudes about MEPA and race issues in foster and adoptive placements in three states. And (5) a qualitative analysis of the content of states' plans for recruiting adoptive parents.As erectile dysfunction treatment disrupts people’s lives and livelihoods and threatens institutions around the world, the need for fast, data-driven solutions to combat the crisis is growing.

The proportion of transracial adoptions—those in which children are not of the same race as either adoptive parent—also increased, from 21 https://friederichsseed.com/lasix-40mg-injection-price percent to 28 percent kamagra best price of all adoptions. Despite this progress, hundreds of thousands of children—more than 50 percent are children of color—currently remain in foster care as they await permanent home placements. In June, the Trump administration issued an executive order that addressed the need to find permanent homes for all children waiting to be adopted. In support, Mathematica partnered with the Assistant Secretary for Planning and Evaluation (ASPE) to explore trends in adoption and attitudes kamagra best price about MEPA.

Our research uncovered essential data about adoptions in the United States, including. Adoptions of Black children in 2017–2019 were 22 percent lower than in 2005–2007, whereas adoptions of White and Hispanic children increased by 41 percent and 36 percent, respectively, in the same time period. The decline in adoptions of Black children was largely due to a declining number of Black kamagra best price children in foster care over the time period (43 percent less). A child’s race is associated with the time spent in foster care before adoption.

Black children adopted between 2017 and 2019 spent the longest time in foster care before adoption—an average of 33 months—compared to 27 months for White children and 28 months for Hispanic children.Raising awareness of these trends in adoption may help federal and state policymakers focus resources, technical support, and outreach strategies to states that need to improve their recruitment and retention of a diverse pool of adoptive and foster parents. To learn more about this work, Mathematica and ASPE released several new research products. (1) a detailed summary of the MEPA study kamagra best price. (2) a graphical fact sheet on trends in adoption and transracial adoption.

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